Recommend both of those people and caregivers with regard to the threats of respiratory melancholy and sedation when OXYCONTIN is utilized with benzodiazepines or other CNS depressants (together with Alcoholic beverages and illicit medication). Advise individuals to not drive or operate weighty equipment until the effects of concomitant use in the benzodiazepine or other CNS depressant happen to be determined.
Oxycodone produces respiratory despair by immediate action on brain stem respiratory facilities. The respiratory melancholy involves a discount inside the responsiveness in the Mind stem respiratory facilities to the two boosts in CO2 rigidity and electrical stimulation.
The oxycodone in OXYCONTIN may bring about spasm on the sphincter of Oddi. Opioids may possibly lead to raises from the serum amylase. Frequently Appraise people with biliary tract sickness, including acute pancreatitis, for worsening symptoms.
Although the threat of dependancy in almost any particular person is unfamiliar, it could possibly happen in people properly prescribed OXYCONTIN. Dependancy can manifest at advised doses and When the drug is misused or abused.
Utilization of bigger setting up doses in sufferers who will be not opioid tolerant could bring about lethal respiratory melancholy [see WARNINGS AND PRECAUTIONS].
To protect versus abnormal publicity to OXYCONTIN by young children, suggest caregivers to strictly adhere to proposed OXYCONTIN dosing.
The ratio in between methadone and various opioid agonists may well differ greatly like a operate of previous dose exposure. Methadone has an extended 50 %-life and may accumulate inside the plasma.
Patients at high possibility of OXYCONTIN abuse consist of People which has a record of extended use of any opioid, which includes items made up of more info oxycodone, All those which has a history of drug or Liquor abuse, or individuals who use OXYCONTIN in combination with other abused drugs.
To click here scale back the potential risk of dizziness and lightheadedness, get up gradually when increasing from a sitting down or lying position.
Evaluate patients for signs of diminished diuresis and/or results on blood pressure level and raise the dosage of your diuretic as required.
If concomitant use is warranted, routinely Consider the patient, specially in the course of procedure initiation and here dose adjustment. Discontinue OXYCONTIN if serotonin syndrome is suspected.
Accidental ingestion of even just one dose, specifically in kids, may lead to a fatal overdose of oxycodone.
Be aware that this checklist isn't all-inclusive and consists of only popular medicines that could communicate with OxyContin. You should consult with the prescribing details for OxyContin for a complete list of interactions.
A Health care Specialist ought to be consulted ahead of taking any drug, changing any diet program or commencing or discontinuing any system of treatment method.